nephroprotective activity of mammea africana stem bark against paracetamol induced kidney injury

نویسندگان

jude efiom okokon

bawo michael

چکیده

background & aim: mammea africana sabine (guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. experimental:  the nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (k+, na+, cl- and hco-3),  antioxidant enzymes (superoxide dismutase (sod), catalase (cat), reduced glutathione (gsh), malondialdehyde (mda) and histopathological study of the liver. results & discussion: the administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. the electrolytes levels were not affected. histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. the chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of m. africana recommended applications/industries: the results show that the stembark extract of mammea africana has nephroprotective potential which may be due to its antioxidant effect activity.

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Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

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Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

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Hepatoprotective activity of Mammea africana ethanol stem bark extract

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hepatoprotective activity of mammea africana ethanol stem bark extract

mammea africana sabine (guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. the hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, to...

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عنوان ژورنال:
journal of herbal drugs (an international journal on medicinal herbs)

ناشر: research center for medicinal plants & ethno-veterinary, i.a.u., shahrekord branch

ISSN 2008-8884

دوره 5

شماره 1 2014

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